The two candidates will square off Sunday evening in Spokane at Gonzaga University.
Murray, A Democrat first elected in 1992, has said if voters return her to the Senate one of her priorities will be higher education and addressing high tuition costs and onerous student loans.
Vance is a former state GOP chairman and King County councilman. He has blamed Murray for congressional gridlock and for not addressing deficit spending. Early in the campaign Vance dismissed his party’s presidential nominee, Donald Trump, saying the New York businessman was too divisive.
A Republican has not won a U.S. Senate race in Washington state since 1994.
The debate can be watched via the stream below.